Mydata

This is Curated Data

WT Data ( kinetic or thermodynamic data of wild type )

MT Data ( kinetic or thermodynamic data of mutant type )

Protein	Mutation(s)_PDB	Protein 1	Protein 2	PubMed ID	WT Data	MT Data	Method
4EKC_A_B	RA183C/EA119A/KA120A	Guanine nucleotide-binding protein G(q) subunit alpha	Regulator of G-protein signaling 2	23434405	IC50=0.27 ± 0.06 uM LogEC50 (n)=2.1 ± 0.03 nM (20)	Log EC50 (n)=1.5 ± 0.06 nM (7)	flow-cytometry-based assay，25°C
4EKC_A_B	RA183C/RA214A	Guanine nucleotide-binding protein G(q) subunit alpha	Regulator of G-protein signaling 2	23434405	IC50=0.27 ± 0.06 uM LogEC50 (n)=2.1 ± 0.03 nM (20)	Log EC50 (n)=2.0 ± 0.04 nM (3)	flow-cytometry-based assay，25°C
4FZA_A_B	FA178E	Calcium-binding protein 39, Mo25-like	Serine/threonine-protein kinase MST4	23434407	Kd=99.1nM	Kd=22.8 nM	Flow Cytometry，25°C
4FZA_A_B	YA223A	Calcium-binding protein 39, Mo25-like	Serine/threonine-protein kinase MST4	23434407	Kd=99.1nM	Kd=77.9 nM	Flow Cytometry，25°C
4FZA_A_B	RA227A	Calcium-binding protein 39, Mo25-like	Serine/threonine-protein kinase MST4	23434407	Kd=99.1nM	Kd=51.7 nM	Flow Cytometry，25°C
4FZA_A_B	EB138A	Calcium-binding protein 39, Mo25-like	Serine/threonine-protein kinase MST4	23434407	Kd=99.1nM	Kd=16.7 nM	Flow Cytometry，25°C
4GKO_A_GHI	SA252A	calcium2+-bound human IgE-Fc(epsilon)3-4	B cell receptor derCD23	23775083	KD=1.5mM	KD=1.5 mM	Flow Cytometry，25°C
4GKO_A_GHI	NA292A	calcium2+-bound human IgE-Fc(epsilon)3-4	B cell receptor derCD23	23775083	KD=1.5mM	KD=0.73 mM	Flow Cytometry，25°C
4GKO_A_GHI	NA292D	calcium2+-bound human IgE-Fc(epsilon)3-4	B cell receptor derCD23	23775083	KD=1.5mM	KD=1.47 mM	Flow Cytometry，25°C
4GNK_A_B	KA311A	Guanine nucleotide-binding protein G(q) subunit alpha	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	23377541	Ki=220±30nM(N=24) EC50=120±30 nM	Ki=260±39 nM(N=4) EC50=130±21 nM	Flow cytometry protein-interaction assay (FCPIA)，25°C

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